Nabil G Seidah Selected Research

Caffeine (No Doz)

1/2022

Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.

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Nabil G Seidah Research Topics

Disease

23	Neoplasms (Cancer) 01/2023 - 06/2002
21	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2021 - 06/2003
16	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 10/2004
14	Atherosclerosis 01/2019 - 02/2004
13	Neoplasm Metastasis (Metastasis) 01/2023 - 06/2002
13	Hypercholesterolemia 10/2022 - 10/2006
13	Infections 01/2022 - 11/2003
8	Virus Diseases (Viral Diseases) 12/2022 - 01/2005
7	Inflammation (Inflammations) 12/2022 - 02/2010
7	Insulin Resistance 01/2021 - 08/2013
6	Melanoma (Melanoma, Malignant) 01/2023 - 12/2010
6	Carcinoma (Carcinomatosis) 01/2008 - 04/2003
5	Carcinogenesis 01/2023 - 04/2003
5	Hepatocellular Carcinoma (Hepatoma) 01/2017 - 06/2013
4	Coronary Disease (Coronary Heart Disease) 01/2018 - 06/2003
4	Dyslipidemias (Dyslipidemia) 12/2016 - 07/2007
4	Alzheimer Disease (Alzheimer's Disease) 01/2011 - 12/2004
4	Vascular Remodeling 10/2004 - 03/2003
3	Septic Shock (Toxic Shock Syndrome) 12/2022 - 04/2012
3	COVID-19 01/2022 - 01/2021
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2020 - 03/2012
3	Fatty Liver 01/2019 - 11/2007
3	Sepsis (Septicemia) 07/2018 - 12/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2013 - 10/2006
2	Non-alcoholic Fatty Liver Disease 01/2024 - 12/2019
2	Dengue (Dengue Fever) 12/2022 - 10/2020
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2021 - 01/2021
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 01/2017
2	Colorectal Neoplasms (Colorectal Cancer) 12/2019 - 01/2008
2	Neuroinflammatory Diseases 10/2019 - 11/2015
2	Fragile X Syndrome (Martin Bell Syndrome) 10/2019 - 01/2017
2	Neuroblastoma 10/2019 - 03/2003
2	Neurocognitive Disorders (Clerambault Syndrome) 10/2019 - 11/2015
2	Vascular Calcification 02/2016 - 01/2013
2	Weight Loss (Weight Reduction) 01/2013 - 03/2012
2	Ischemic Stroke 11/2012 - 07/2011
2	Brain Neoplasms (Brain Tumor) 10/2012 - 12/2010
2	Hypertrophy 04/2011 - 01/2011
2	Human Influenza (Influenza) 10/2008 - 07/2008
2	Infertility (Sterility) 10/2008 - 10/2006
2	Communicable Diseases (Infectious Diseases) 10/2008 - 10/2006
2	Atherosclerotic Plaque (Atheroma) 05/2005 - 02/2004
1	Hyperlipidemias (Hyperlipidemia) 12/2022

Drug/Important Bio-Agent (IBA)

33	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 01/2020 - 06/2002
22	LDL Receptors (LDL Receptor)IBA 01/2023 - 06/2003
22	FurinIBA 01/2022 - 03/2003
17	CholesterolIBA 01/2024 - 01/2007
17	LDL CholesterolIBA 01/2023 - 06/2003
17	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
14	Proprotein Convertase 9IBA 01/2021 - 06/2003
12	SubtilisinIBA 11/2018 - 04/2005
11	LipidsIBA 01/2024 - 10/2006
11	oxidized low density lipoproteinIBA 01/2019 - 01/2010
11	tetrapeptide carbamateIBA 01/2015 - 03/2003
6	Messenger RNA (mRNA)IBA 01/2024 - 03/2003
6	ApolipoproteinsIBA 01/2024 - 06/2003
6	Monoclonal AntibodiesIBA 12/2022 - 05/2015
6	LDL Lipoproteins (beta Lipoproteins)IBA 01/2017 - 10/2009
5	PCSK9 InhibitorsIBA 12/2022 - 01/2013
5	Small Interfering RNA (siRNA)IBA 12/2022 - 01/2008
5	Lipoprotein(a)IBA 10/2022 - 05/2015
5	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 08/2008
5	Insulin (Novolin)FDA Link 01/2021 - 05/2005
5	Antiviral Agents (Antivirals)IBA 01/2021 - 08/2005
5	CytokinesIBA 10/2019 - 04/2012
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2022 - 08/2004
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2010
4	Peptides (Polypeptides)IBA 01/2020 - 03/2003
4	EnzymesIBA 10/2008 - 09/2004
3	HDL CholesterolIBA 10/2021 - 10/2009
3	Apolipoproteins B (ApoB)IBA 01/2021 - 06/2003
3	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2021 - 03/2002
3	Triglycerides (Triacylglycerol)IBA 12/2019 - 04/2011
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 04/2004
3	Amyloid (Amyloid Fibrils)IBA 01/2011 - 06/2002
3	Amyloid beta-PeptidesIBA 02/2010 - 12/2004
3	Matrix Metalloproteinase 14 (MT1-MMP)IBA 05/2005 - 08/2004
3	IntegrinsIBA 04/2005 - 02/2004
2	FructoseIBA 01/2024 - 04/2015
2	RNA (Ribonucleic Acid)IBA 01/2023 - 10/2018
2	VaccinesIBA 01/2021 - 01/2013
2	LipopolysaccharidesIBA 07/2018 - 04/2012
2	SterolsIBA 01/2017 - 10/2006
2	IronIBA 03/2016 - 06/2013
2	Chelating AgentsIBA 03/2016 - 06/2013
2	InterleukinsIBA 02/2016 - 11/2015
2	Biomarkers (Surrogate Marker)IBA 12/2015 - 03/2012
2	LigandsIBA 12/2013 - 10/2009
2	Cadherins (E-Cadherin)IBA 10/2012 - 12/2010
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2009 - 12/2004
2	Vascular Endothelial Growth Factor CIBA 05/2005 - 06/2003
2	Integrin alphaVIBA 02/2004 - 03/2003
2	protease SIBA 06/2003 - 04/2003
1	Immune Checkpoint InhibitorsIBA 01/2023
1	Fas Ligand Protein (Fas Ligand)IBA 01/2023
1	AgarIBA 01/2023
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 12/2022

Therapy/Procedure

8	Therapeutics 01/2023 - 06/2002
2	Injections 12/2022 - 01/2021
1	Immunotherapy 12/2022